The idea that you would see such a huge benefit so quickly is hard to accept.

I felt that that committee that voted 8-to-1 was simply missing the boat, ... I didn't think they connected the dots.

I'm not a crusader, I just want the balance between safety and efficacy to be favorable.

That's always been just a dream -- actually making the disease go away.

It's really the next generation. It ought to be a magic bullet.

I want to cause people's hands to tremble a little bit before they write that (prescription). The only way I know how to do that is to put it in a black box.

I treated this as a public health emergency, ... A drug that had an 8-to-1 vote in favor of approval and that could any day be approved by the FDA to be used by any of 18 million Americans with type 2 diabetes was, by my analysis, doubling of risk of serious irrevocable cardiovascular events like death, heart attacks and stroke. I dropped everything.

This may be the beginning of a real revolution in the treatment of heart disease. We're not merely slowing down the inexorable progression but truly reversing the disease. It's very exciting.

Ten of 1,000 patients would die, have a heart attack or a stroke. Those are serious irrevocable events.

There's only one way -- through good science. We know the burden is upon us to do this right.